CDK8 (N-term) Peptide
产品名称： CDK8 (N-term) Peptide
英文名称： CDK8 (N-term) Peptide
产品编号： P2529
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CDK8.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human CDK8.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- TFIIH is negatively regulated by cdk8-containing mediator complexes.
Akoulitchev S, Chuikov S, Reinberg D.Nature. 2000 Sep 7;407(6800):102-6.
- 2.
- Genomics of the human genes encoding four TAFII subunits of TFIID, the three subunits of TFIIA, as well as CDK8 and SURB7.
Di Pietro C, Rapisarda A, Bonaiuto C, Lizzio MN, Engel H, Amico V, Scalia M, Amato A, Grzeschik KH, Sichel G, Purrello M.Somat Cell Mol Genet. 1999 May;25(3):185-9.
- 3.
- Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases.
Rickert P, Corden JL, Lees E.Oncogene. 1999 Jan 28;18(4):1093-102.
- Entrez GeneID:
- 1024
- Protein Accession#:
- P49336
- Gene Name:
- CDK8
- Gene Alias:
- K35,MGC126074,MGC126075
- Gene Description:
- cyclin-dependent kinase 8
- Omim ID:
- 603184
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq
- Other Designations:
- CDK8 protein kinase,OTTHUMP00000018158,cell division protein kinase 8,protein kinase K35