FITC标记的A激酶锚定蛋白5抗体
产品名称： FITC标记的A激酶锚定蛋白5抗体
英文名称： Anti-AKAP5/FITC
产品编号： HZ-6980R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-AKAP5/FITC Conjugated antibody
FITC标记的A激酶锚定蛋白5抗体
| 产品编号 | bs-6980R-FITC |
| 英文名称 | Anti-AKAP5/FITC |
| 中文名称 | FITC标记的A激酶锚定蛋白5抗体 |
| 别 名 | AKAP 150;A kinase (PRKA) anchor protein 5; A kinase anchor protein 5; A kinase anchor protein 79kDa; A kinase anchoring protein 75/79; A-kinase anchor protein 5; A-kinase anchor protein 79 kDa; AKAP 5; AKAP 75; AKAP 79; AKAP-5; Akap5; AKAP5_HUMAN; AKAP75; AKAP79; cAMP dependent protein kinase regulatory subunit II high affinity binding protein; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; H21. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 47/79(human/rat, mo)kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AKAP5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates (1). Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. This family of proteins has been designated A-kinase anchoring proteins (AKAP) (1-3). Members of this family, including MAP2 (microtubule-associated protein 2), neuronally expressed AKAP 79 and AKAP 150, and the DNA binding AKAP 95, display differential tissue specificity and localization (4-6). Evidence suggests that AKAP 79 and AKAP 150 are both capable of anchoring PKA to postsynaptic densities (PSD), which are a network of proteins located on the internal surfaces of excitatory synapses。 Function: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Subunit: Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C (By similarity). Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. Subcellular Location: Membrane; Lipid-anchor. Tissue Specificity: Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary. Post-translational modifications: Palmitoylation at Cys-36 and Cys-129 plays a key role in targeting to lipid rafts. Similarity: Contains 1 AKAP domain. Database links: UniProtKB/Swiss-Prot: P24588.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
II型cAMP蛋白激酶（PKA）是具有广泛底物（1）的多功能激酶。PKA信号的特异性被认为是由激酶在细胞内的特定位点的介导介导的。为了保持这一特定的定位，PKA的R亚基（RII）与特定的RII锚定蛋白相互作用。这一家族蛋白已被命名为A激酶锚定蛋白（AKAP）（1-3）。这个家族的成员，包括MAP2（微管相关蛋白2），神经元表达的AkAP 79和AkAP 150，和DNA结合的AkAP 95，显示差异的组织特异性和定位（4-6）。有证据表明AkAP 79和AkAP 150都能够将PKA锚定到突触后密度（PSD），这是位于兴奋性突触的内表面上的蛋白质网络。