CBL polyclonal antibody
产品名称： CBL polyclonal antibody
英文名称： CBL polyclonal antibody
产品编号： PAB18167
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CBL.
- Immunogen:
- A synthetic peptide corresponding to human CBL.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to CBL.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells.
Loeser S, Loser K, Bijker MS, Rangachari M, van der Burg SH, Wada T, Beissert S, Melief CJ, Penninger JM.J Exp Med. 2007 Apr 16;204(4):879-91. Epub 2007 Apr 2.
- 2.
- Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells.
Yi Y, McNerney M, Datta SK.J Immunol. 2000 Dec 1;165(11):6627-34.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from HepG2 cells, treated with Na2VO3 (0.3 nM, 40 mins), using CBL polyclonal antibody (Cat # PAB18167).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 867
- Protein Accession#:
- P22681
- Gene Name:
- CBL
- Gene Alias:
- C-CBL,CBL2,RNF55
- Gene Description:
- Cas-Br-M (murine) ecotropic retroviral transforming sequence
- Omim ID:
- 165360
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq
- Other Designations:
- oncogene CBL2