XRCC3 monoclonal antibody, clone 10F1/6
产品名称： XRCC3 monoclonal antibody, clone 10F1/6
英文名称： XRCC3 monoclonal antibody, clone 10F1/6
产品编号： MAB2393
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant XRCC3.
- Immunogen:
- Recombinant His fusion protein corresponding to human XRCC3.
- Host:
- Mouse
- Reactivity:
- Bovine, Human, Primates, Rat, Sheep
- Specificity:
- This antibody is specific to XRCC3.
- Form:
- Liquid
- Isotype:
- IgG1, kappa
- Storage Buffer:
- In PBS, pH 7.4 (0.1% sodium azide)
- Storage Instruction:
- Store at 4°C. Do not freeze.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- Recommend Usage:
- Western Blot (1:1000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Dysfunctional homologous recombination mediates genomic instability and progression in myeloma.
Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC.Blood. 2009 Mar 5;113(10):2290-7. Epub 2008 Dec 2.
- 2.
- WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.
Li B, Jog SP, Reddy S, Comai L.Mol Cell Biol. 2008 Mar;28(6):1892-904. Epub 2008 Jan 22.
- 3.
- Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.
Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B, Bristow RG.Cancer Res. 2008 Jan 15;68(2):605-14.
- 4.
- Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
Compton SA, Choi JH, Cesare AJ, Ozgur S, Griffith JD.Cancer Res. 2007 Feb 15;67(4):1513-9.
- 5.
- Increased MMP-2 expression in connective tissue growth factor over-expression vascular smooth muscle cells.
Fan WH, Karnovsky MJ.J Biol Chem. 2002 Mar 22;277(12):9800-5. Epub 2001 Dec 28.
- Entrez GeneID:
- 7517
- Protein Accession#:
- O43542
- Gene Name:
- XRCC3
- Gene Alias:
- -
- Gene Description:
- X-ray repair complementing defective repair in Chinese hamster cells 3
- Omim ID:
- 600675
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq
- Other Designations:
- DNA repair protein XRCC3,RAD51-like,X-ray repair cross complementing protein 3,X-ray-repair, complementing defective, repair in Chinese hamster
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Adenoma
- Astrocytoma
- Ataxia telangiectasia
- Barrett Esophagus
- Biliary Tract Neoplasms
- Bone Neoplasms
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Basal Cell
- Carcinoma, Ductal
- Carcinoma, Ductal, Breast
- Carcinoma, Hepatocellular
- Carcinoma, Lobular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Pancreatic Ductal
- Carcinoma, Papillary