TMEM59 Antibody
产品名称： TMEM59 Antibody
英文名称： TMEM59 Antibody
产品编号： 254388
产品价格： null
产品产地： 美国
品牌商标： Abbiotec
更新时间： null
使用范围： E: 1:500-1:1,000; WB: 1:100-1:500
深圳市豪地华拓生物科技有限公司
- 联系人 :
- 地址 : 深圳市南山创业路中兴城5栋518
- 邮编 : 518054
- 所在区域 : 广东
- 电话 : 132****4656 点击查看
- 传真 : 点击查看
- 邮箱 : order@otwobiotech.com
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.