Anti-CD8 Polyclonal Antibody

英文名称
Anti-CD8 Polyclonal Antibody
别名
CD8A;MAL;Leu2;p32;OKT8 T cell antigen
应用
WB
稀释比例
WB 1:3000.
交叉反应
Mouse
蛋白分子量
28kDa
Gene ID
925
保存
Store at -20°C. Avoid freeze / thaw cycles.
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法
Affinity purification
亚型
IgG
免疫原
A synthetic peptide of human CD8
性状
液体
Public 
Immunogen
Range
A synthetic peptide of human CD8
Subcellular 
Locations
Cell membrane
Swiss Prot
P01732
克隆类型
Polyclonal Antibody
背景资料
Integral membrane glycoprotein that plays an essential 
role in the immune response and serves multiple 
functions in responses against both external and 
internal offenses. In T-cells, functions primarily as a 
coreceptor for MHC class I molecule:peptide complex. 
The antigens presented by class I peptides are derived 
from cytosolic proteins while class II derived from 
extracellular proteins. Interacts simultaneously with the 
T-cell receptor (TCR) and the MHC class I proteins 
presented by antigen presenting cells (APCs). In turn, 
recruits the Src kinase LCK to the vicinity of the TCR-
CD3 complex. LCK then initiates different intracellular 
signaling pathways by phosphorylating various 
substrates ultimately leading to lymphokine 
production, motility, adhesion and activation of 
cytotoxic T-lymphocytes (CTLs). This mechanism 
enables CTLs to recognize and eliminate infected cells 
and tumor cells. In NK-cells, the presence of CD8A 
homodimers at the cell surface provides a survival 
mechanism allowing conjugation and lysis of multiple 
target cells. CD8A homodimer molecules also promote 
the survival and differentiation of activated 
lymphocytes into memory CD8 T-cells.