FITC标记的Kelch样蛋白2抗体
产品名称： FITC标记的Kelch样蛋白2抗体
英文名称： Anti-KLHL2/FITC
产品编号： HZ-16767R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-KLHL2/FITC Conjugated antibody
| FITC标记的Kelch样蛋白2抗体 |
| 英文名称 | Anti-KLHL2/FITC |
| 中文名称 | FITC标记的Kelch样蛋白2抗体 |
| 别 名 | ABP KELCH; Actin binding protein Mayven; Actin-binding protein Mayven; kelch; kelch like 2; Kelch like protein 2; Kelch-like protein 2; KLHL2; KLHL2_HUMAN; MAV; MAYVEN; OTTHUMP00000219997; OTTHUMP00000219998. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 结合蛋白 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 66kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KLHL2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: KLHL2 is a 593 amino acid actin-binding protein. Highly expressed in brain, KLHL2 is thought to play a role in the organization of the actin cytoskeleton in brain cells. KLHL3 (kelch-like protein 3), is a 587 amino acid protein active in the protein ubiquitination pathway. KLHL3 is thought to be a substrate-specific adapter of an E3 ubiquitin-ligase complex that mediates the ubiquitination of target proteins, which leads to proteasomal degradation of the target protein. KLHL2 and KLHL3 proteins contain six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. Function: May play a role in organizing the actin cytoskeleton of the brain cells. Subcellular Location: Cytoplasm > cytoskeleton. Tissue Specificity: Predominantly expressed in brain. Similarity: Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats. Database links: Entrez Gene: 11275 Human Omim: 605774 Human SwissProt: O95198 Human Unigene: 388668 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
KLHL2是一个593氨基酸的肌动蛋白结合蛋白。在脑中高表达，KLHL2被认为在脑细胞肌动蛋白细胞骨架的组织中起作用。KLHL3（KelCH样蛋白3）是蛋白质泛素化途径中具有活性的587氨基酸蛋白。KLHL3被认为是E3泛素-连接酶复合物的底物特异性适配器，该复合物介导靶蛋白的泛素化，从而导致靶蛋白的蛋白酶体降解。KLHL2和KLHL3蛋白含有六个KalCH重复序列和一个BTB（POZ）结构域。BTB(Broad-Complex，Tram.and Bric a brac)结构域，也称为POZ(Poxvirus and Zinc finger)结构域，是一个N端同态化结构域，包含多个海带重复序列和/或C2H2型锌指。含有BTB结构域的蛋白质被认为通过控制染色质结构和功能参与转录调节。