MATK polyclonal antibody
产品名称： MATK polyclonal antibody
英文名称： MATK polyclonal antibody
产品编号： PAB3432
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MATK.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MATK.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells.
Zagozdzon R, Bougeret C, Fu Y, Avraham HK.Int J Oncol. 2002 Dec;21(6):1347-52.
- 2.
- Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer.
Kim S, Zagozdzon R, Meisler A, Baleja JD, Fu Y, Avraham S, Avraham H.J Biol Chem. 2002 Sep 27;277(39):36465-70. Epub 2002 Jul 16.
- 3.
- Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells.
Zrihan-Licht S, Lim J, Keydar I, Sliwkowski MX, Groopman JE, Avraham H.J Biol Chem. 1997 Jan 17;272(3):1856-63.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of MATK polyclonal antibody (Cat # PAB3432) in mouse thymus tissue lysate. MATK (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with MATK polyclonal antibody (Cat # PAB3432) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 4145
- Protein Accession#:
- P42679
- Gene Name:
- MATK
- Gene Alias:
- CHK,CTK,DKFZp434N1212,HHYLTK,HYL,HYLTK,Lsk,MGC1708,MGC2101
- Gene Description:
- megakaryocyte-associated tyrosine kinase
- Omim ID:
- 600038
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- Csk-homologous kinase,Csk-type protein tyrosine kinase,HYL tyrosine kinase,hematopoietic consensus tyrosine-lacking kinase,hydroxyaryl-protein kinase,leukocyte carboxyl-terminal src kinase related,protein kinase HYL,tyrosine kinase MATK,tyrosine-protein k