ITGAV Pre-design Chimera RNAi
产品名称： ITGAV Pre-design Chimera RNAi
英文名称： ITGAV Pre-design Chimera RNAi
产品编号： H00003685-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) (ITGAV), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_002210
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 3685
- Gene Name:
- ITGAV
- Gene Alias:
- CD51,DKFZp686A08142,MSK8,VNRA
- Gene Description:
- integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
- Omim ID:
- 193210
- Gene Ontology:
- Hyperlink
- Gene Summary:
- ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq
- Other Designations:
- Integrin, alpha-V (vitronectin receptor, alpha polypeptide),antigen identified by monoclonal antibody L230,integrin alpha-V
- Related Disease
- Anemia, Sickle Cell
- Anemia, sickle cell
- Arthritis, Rheumatoid
- Breast cancer
- Breast Neoplasms
- Carcinoma, Hepatocellular
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Hepatitis B, Chronic
- Ovarian Neoplasms
- Priapism
- Thalassemia
- Thalassemia
- Tobacco Use Disorder