FITC标记的多磷酸肌醇激酶IPMK抗体
产品名称： FITC标记的多磷酸肌醇激酶IPMK抗体
英文名称： Anti-IPMK/FITC
产品编号： HZ-12385R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-IPMK/FITC Conjugated antibody
FITC标记的多磷酸肌醇激酶IPMK抗体
| 英文名称 | Anti-IPMK/FITC |
| 中文名称 | FITC标记的多磷酸肌醇激酶IPMK抗体 |
| 别 名 | 6-tetrakisphosphate 5-kinase; Inositol 1; Inositol 1,3,4,6 tetrakisphosphate 5 kinase; Inositol polyphosphate multikinase; Ipmk; IPMK_HUMAN |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 信号转导 干细胞 转录调节因子 激酶和磷酸酶 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 47kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IPMK |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Inositol polyphosphate multikinase (IPMK) belongs to the inositol phosphokinase (IPK) family and is characterized as having a broad substrate specificity. However, IPMK displays a preference for inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). IPMK is ubiquitously expressed with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon. IPMK is localized to the nucleus, where it may play a role in the regulation of calcium release from intracellular stores and has been implicated as a drug target for cancer therapies. The gene encoding IPMK maps to human chromosome 10, which contains over 800 genes. Notably, disorders linked to genes on chromosome 10 include Cowden syndrome, Cockayne syndrome and Tetrahydrobiopterin deficiency. Function: Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon. Similarity: Belongs to the inositol phosphokinase (IPK) family. Database links: UniProtKB/Swiss-Prot: Q8NFU5.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
肌醇多磷酸激酶（IPMK）属于肌醇磷酸激酶（IPK）家族，具有广泛的底物特异性。然而，IPMK显示出对肌醇-1，4，5-三磷酸（Ins（1，4，5）P3）和肌醇-1，3，4，6-四磷酸（Ins（1，3，4，6）P4）的偏好。IPMK在骨骼肌、肝脏、胎盘、肺、外周血白细胞、肾脏、脾脏和结肠中表达最高。IPMK定位于细胞核，在细胞核中可能发挥调节细胞内钙释放的作用，并已被作为癌症治疗的药物靶点。编码IPMK的基因定位于人类染色体10，包含800个以上的基因。值得注意的是，与第10号染色体上的基因有关的疾病包括Cordon综合征、Coojne综合征和四氢生物蝶呤缺乏症。