FITC标记的G蛋白信号转导调节因子17抗体
产品名称： FITC标记的G蛋白信号转导调节因子17抗体
英文名称： Anti-RGS17/FITC
产品编号： HZ-19857R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RGS17/FITC Conjugated antibody
FITC标记的G蛋白信号转导调节因子17抗体
| 英文名称 | Anti-RGS17/FITC |
| 中文名称 | FITC标记的G蛋白信号转导调节因子17抗体 |
| 别 名 | Regulator of G protein signalling 17; RGS17 / RGSZ2; Regulator of G protein signalling Z2; Regulator of G-protein signaling 17; RGS17; RGS17_HUMAN; RGSZ2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RGS17 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. Subcellular Location: Membrane. Nucleus. Cytoplasm. Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation. Tissue Specificity: Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes. Post-translational modifications: Fatty acylated. Heavily palmitoylated in the cysteine string motif. N- and O-glycosylated in synapsomal membranes. Serine phosphorylated in synapsomal membranes. Sumoylated by SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits. Similarity: Contains 1 RGS domain. Database links: Entrez Gene: 504255 Cow Entrez Gene: 608867 Dog Entrez Gene: 100712640 Guinea pig Entrez Gene: 100060098 Horse Entrez Gene: 26575 Human Entrez Gene: 56533 Mouse Entrez Gene: 100514020 Pig Entrez Gene: 100349762 Rabbit Entrez Gene: 308118 Rat Omim: 607191 Human SwissProt: Q9UGC6 Human SwissProt: Q9QZB0 Mouse Unigene: 166313 Human Unigene: 44606 Mouse Unigene: 166916 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码G蛋白信号家族的调节成员。这种蛋白质包含一个保守的，120个氨基酸基序，称为RGS结构域和富含半胱氨酸的区域。该蛋白通过与活化的GTP结合的Gα亚基结合并充当GTP酶激活蛋白(GAP)来减弱G蛋白的信号转导活性，从而提高GTP向GDP的转化率。这种水解允许Gα亚基结合Gβ/γ亚基异二聚体，形成非活性的G蛋白异三聚体，从而终止信号。[ RefSeq，JUL 2008 ]