PRKCG polyclonal antibody
产品名称： PRKCG polyclonal antibody
英文名称： PRKCG polyclonal antibody
产品编号： PAB4539
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PRKCG.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PRKCG.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma.
Yabe I, Sasaki H, Chen DH, Raskind WH, Bird TD, Yamashita I, Tsuji S, Kikuchi S, Tashiro K.Arch Neurol. 2003 Dec;60(12):1749-51.
- 2.
- Identification of a novel SCA14 mutation in a Dutch autosomal dominant cerebellar ataxia family.
van de Warrenburg BP, Verbeek DS, Piersma SJ, Hennekam FA, Pearson PL, Knoers NV, Kremer HP, Sinke RJ.Neurology. 2003 Dec 23;61(12):1760-5.
- 3.
- Isoform-specific phosphorylation of metabotropic glutamate receptor 5 by protein kinase C (PKC) blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC.
Uchino M, Sakai N, Kashiwagi K, Shirai Y, Shinohara Y, Hirose K, Iino M, Yamamura T, Saito N.J Biol Chem. 2004 Jan 16;279(3):2254-61. Epub 2003 Oct 15.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of PRKCG polyclonal antibody (Cat # PAB4539) in mouse brain lysate . PRKCG (arrow) was detected using purified PRKCG polyclonal antibody (Cat # PAB4539) . Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence .
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human brain tissue reacted with PRKCG polyclonal antibody (Cat # PAB4539) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated .
- Entrez GeneID:
- 5582
- Protein Accession#:
- P05129
- Gene Name:
- PRKCG
- Gene Alias:
- MGC57564,PKC-gamma,PKCC,PKCG,SCA14
- Gene Description:
- protein kinase C, gamma
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq
- Other Designations:
- -
- Gene Pathway
- Calcium signaling pathway
- ErbB signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- Gap junction
- Glioma
- Leukocyte transendothelial migration
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Natural killer cell mediated cytotoxicity
- Non-small cell lung cancer
- Pathways in cancer
- Phosphatidylinositol signaling system
- Tight junction
- Vascular smooth muscle contraction
- VEGF signaling pathway
- Vibrio cholerae infection
- Wnt signaling pathway
- Related Disease
- Antisocial Personality Disorder
- Attention Deficit Disorder with Hyperactivity
- Cardiovascular Diseases
- Conduct Disorder
- Depressive Disorder, Major
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Inhibition (Psychology)
- Liver Cirrhosis
- Spinocerebellar ataxia
- Spinocerebellar Ataxias
- Substance-Related Disorders