ALDH3A1 Pre-design Chimera RNAi
产品名称： ALDH3A1 Pre-design Chimera RNAi
英文名称： ALDH3A1 Pre-design Chimera RNAi
产品编号： H00000218-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens aldehyde dehydrogenase 3 family, memberA1 (ALDH3A1), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_000691
- Target Region:
- Coding sequence
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 218
- Gene Name:
- ALDH3A1
- Gene Alias:
- ALDH3,ALDHIII,MGC10406
- Gene Description:
- aldehyde dehydrogenase 3 family, memberA1
- Omim ID:
- 100660
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
- Other Designations:
- aldehyde dehydrogenase 3A1,aldehyde dehydrogenase isozyme 3,aldehyde dehydrogenase type III,aldehyde dehydrogenase, dimeric NADP-preferring,stomach aldehyde dehydrogenase
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- Attention Deficit Disorder with Hyperactivity
- Autistic Disorder
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Ductal, Breast
- Drug Toxicity
- Genetic Predisposition to Disease
- Kidney Failure, Chronic
- NARP
- Neoplasms
- Neoplasms, Germ Cell and Embryonal
- Ovarian cancer
- Ovarian Neoplasms
- Schizophrenia
- Schizophrenia, Paranoid
- Tobacco Use Disorder