FITC标记的β淀粉样蛋白前体结合蛋白B-1抗体
产品名称： FITC标记的β淀粉样蛋白前体结合蛋白B-1抗体
英文名称： Anti-APBB1 interacting protein 1/FITC
产品编号： HZ-6172R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-APBB1 interacting protein 1/FITC Conjugated antibody
FITC标记的β淀粉样蛋白前体结合蛋白B-1抗体
| 英文名称 | Anti-APBB1 interacting protein 1/FITC |
| 中文名称 | FITC标记的β淀粉样蛋白前体结合蛋白B-1抗体 |
| 别 名 | AB1IP; Amyloid beta A4 precursor protein binding family B member 1 interacting protein; Amyloid beta precursor protein binding family B member 1; APBB1 interacting protein 1; OTTHUMP00000019344; PREL 1; PREL1; Proline rich EVH1 ligand 1; Proline rich protein 73; Rap1 GTP interacting adapter molecule; RAP1 interacting adaptor molecule; RARP 1; RARP1; Retinoic acid responsive proline rich protein 1; AB1IP_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 结合蛋白 G蛋白偶联受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 73kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RIAM/APBB1 interacting protein 1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: APBB1IP is a 666 amino acid protein that contains one PH domain, one Ras-associating domain and belongs to the MRL family. Encoded by a gene that maps to human chromosome 10p12.1, APBB1IP likely functions in signal transduction from Ras activation to Actin cytoskeletal remodeling. APBB1IP also suppresses insulin-induced promoter activities, by way of SRE and AP1. The two proline-rich regions of APBB1IP are necessary for AP1 transcription suppression. Ubiquitously expressed, with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes, APBB1IP is induced by all-trans-retinoic acid (ATRA) and mediates Rap 1-induced adhesion. APBB1IP also interacts with RAP 1A, Profilin-1, VASP and Mena. Function: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. Subunit: nteracts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, VASP and ENAH. Subcellular Location: Cell membrane; Peripheral membrane protein (By similarity). Cell projection, lamellipodium (By similarity). Cell junction, focal adhesion (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases. Tissue Specificity: Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes. Similarity: Belongs to the MRL family. Contains 1 PH domain. Database links: Entrez Gene: 54518 Human Entrez Gene: 54519 Mouse Omim: 609036 Human SwissProt: Q7Z5R6 Human SwissProt: Q8R5A3 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ApBB1IP是含有一个pH域、一个Ras结合域的666个氨基酸蛋白，属于MRL家族。APBB1IP编码的基因编码于人染色体10P121，可能在Ras激活信号转导到肌动蛋白细胞骨架重塑中起作用。ApBB1IP还通过SRE和AP1抑制胰岛素诱导的启动子活性。APBB1IP的两个富含脯氨酸的区域是AP1转录抑制所必需的。在胸腺、脾脏、淋巴结、骨髓和外周血白细胞中高表达，APBB1IP通过全反式维甲酸（ATRA）诱导，并介导RAP 1诱导的粘附。APBB1IP还与RAP 1A、PropiL-1、VASP和曼娜相互作用。