FITC标记的S期激酶活化蛋白DBF4B抗体
产品名称： FITC标记的S期激酶活化蛋白DBF4B抗体
英文名称： Anti-DBF4B/FITC
产品编号： HZ-5748R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-DBF4B/FITC Conjugated antibody
FITC标记的S期激酶活化蛋白DBF4B抗体
| 英文名称 | Anti-DBF4B/FITC |
| 中文名称 | FITC标记的S期激酶活化蛋白DBF4B抗体 |
| 别 名 | Activator of S phase kinase like protein 1; ASK like protein 1; ASKL1; chifb; Chiffon homolog B; DBF 4B; DBF4 homolog B (S. cerevisiae); DBF4 homolog B; Dbf4 related factor 1; DRF1; Protein DBF4 homolog B; ZDBF1B; Zinc finger DBF type containing 1B; DBF4B_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 18kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DBF4B/ASKL1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DBF4B is a regulatory subunit for CDC7, a serine-threonine kinase which links cell cycle regulation to genome duplication. The complex CDC7-DBF4B selectively phosphorylates the MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. DBF4B localizes to the nucleus and its expression is cell cycle-regulated. Function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. Subunit: Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4/DBF4A or DBF4B. Such complexes are stable upon replication stress. Subcellular Location: Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction. Tissue Specificity: Widely expressed. Highly expressed in testis. Post-translational modifications: Phosphorylated. Similarity: Contains 1 BRCT domain. Contains 1 DBF4-type zinc finger. Database links: Entrez Gene: 80174 Human Omim: 611661 Human SwissProt: Q8NFT6 Human Unigene: 369998 Human Unigene: 728986 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DbF4B是CDC7的一个调节亚基，它是一种丝氨酸苏氨酸激酶，它将细胞周期调控与基因组复制联系起来。复杂的CDC7 - DbF4B选择性地在“Ser-40”处磷酸化McM2亚基，然后参与调节细胞周期中DNA复制的起始。DbF4B定位于细胞核，其表达受细胞周期调控。