FITC标记的Nogo-66(1-40)抗体
产品名称： FITC标记的Nogo-66(1-40)抗体
英文名称： Anti-NEP1-40/FITC
产品编号： HZ-10509R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NEP1-40/FITC Conjugated antibody
FITC标记的Nogo-66(1-40)抗体
| 英文名称 | Anti-NEP1-40/FITC |
| 中文名称 | FITC标记的Nogo-66(1-40)抗体 |
| 别 名 | Nogo extra cellular peptide residues 1-40; Nogo-66(1-40); Nogo-66(1-40) antagonist peptide; Nogo A; reticulon-4 isoform D; ASY; Foocen; Human NogoA; KIAA0886; My043 protein; Nbla00271; Nbla10545; Neurite growth inhibitor 220; Neurite Outgrowth Inhibitor; Neuroendocrine specific protein; Neuroendocrine specific protein C homolog; NI220/250; Nogo A; NOGO; Nogo protein; NogoA; NSP; NSP CL; Reticulon 4; Reticulon 5; Reticulon4; Reticulon5; RTN 4; RTN 4A; RTN X; RTN xL; RTN4 A; RTN4; RTN4 B1; RTN4 B2; RTN4 C; RTN4 protein; RTN4_HUMAN; Reticulon-4; Neuroendocrine-specific protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22/131kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NEP1-40 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Subunit: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1. Subcellular Location: Endoplasmic reticulum membrane. Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains. Tissue Specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific. Similarity: Contains 1 reticulon domain. Database links: Entrez Gene: 57142 Human Entrez Gene: 68585 Mouse Entrez Gene: 83765 Rat Omim: 604475 Human SwissProt: Q9NQC3 Human SwissProt: Q99P72 Mouse SwissProt: Q9JK11 Rat Unigene: 704007 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
该基因属于网状内皮编码基因家族。网状细胞与内质网相连，参与神经内分泌分泌或神经内分泌细胞的膜运输。这个基因的产物是一种强有力的神经突起生长抑制剂，它也可能有助于阻止高等脊椎动物中枢神经系统的再生。已经鉴定了源自差异剪接和差异启动子使用以及编码不同异构体的选择性剪接转录变体。[ RefSeq，JUL 2008 ]提供。