FITC标记的磷酸化GATA结合蛋白3抗体
产品名称： FITC标记的磷酸化GATA结合蛋白3抗体
英文名称： Anti-phospho-GATA3 (Ser115)/FITC
产品编号： HZ-10279R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-phospho-GATA3 (Ser115)/FITC Conjugated antibody
FITC标记的磷酸化GATA结合蛋白3抗体
| 英文名称 | Anti-phospho-GATA3 (Ser115)/FITC |
| 中文名称 | FITC标记的磷酸化GATA结合蛋白3抗体 |
| 别 名 | GATA3 (phospho S115); p-GATA3 (phospho S115); GATA3 (phospho Ser115); p-GATA3 (Ser115); GATA 3; GATA3; GATA-3; GATA binding factor 3; GATA binding protein 3; HDR; MGC2346; MGC5199; MGC5445; Trans acting T cell specific transcription factor GATA 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, Danio rerio |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human GATA3 around the phosphorylation site of Ser115 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites. Function: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Subcellular Location: Nucleus. Tissue Specificity: T-cells and endothelial cells. DISEASE: Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome. Similarity: Contains 2 GATA-type zinc fingers. Database links: Entrez Gene: 2625 Human Entrez Gene: 14462 Mouse Entrez Gene: 85471 Rat Omim: 131320 Human SwissProt: P23771 Human SwissProt: P23772 Mouse Unigene: 524134 Human Unigene: 313866 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
GATA家族的成员共享一个保守的锌指DNA结合结构域，并且能够结合WGATAR共识序列。GATA-1是红系特异性的，负责调控红系基因转录。它是红系血统的重要组成部分。GATA-2在胚胎脑和肝、HeLa和内皮细胞以及红系细胞中表达。用改进的GATA共识序列AGATCTTA进行的研究表明，GATA-2和GATA-3识别这种突变的共识而GATA-1识别这种序列的能力较差。这表明GATA-2和GATA-3比GATA-1更广泛的调节能力。GATA-3在T淋巴细胞中高表达。GATA-4、GATA-5和GATA-6是转录因子家族的一个亚家族。GATA-4和GATA-6均存在于心脏、胰腺和卵巢；肺和肝组织表现为GATA-6，但不表达GATA－4。GATA-5在已分化的心脏和肠组织中已观察到表达，并存在于心脏的整个发育过程中。虽然各种GATA转录因子的表达模式可能重叠，但是GATA因子在结合其适当的靶位点方面如何能够区分还不清楚。