FITC标记的磷酸化葡萄糖合成酶1抗体
产品名称： FITC标记的磷酸化葡萄糖合成酶1抗体
英文名称： Anti-Phospho-Glycogen synthase 1(Ser641)/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Phospho-Glycogen synthase 1(Ser641)/FITC Conjugated antibody
FITC标记的磷酸化葡萄糖合成酶1抗体
| 产品编号 | bs-3190R-FITC |
| 英文名称 | Anti-Phospho-Glycogen synthase 1(Ser641)/FITC |
| 中文名称 | FITC标记的磷酸化葡萄糖合成酶1抗体 |
| 别 名 | Glycogen synthase 1 (phospho S641); Glycogen synthase 1 (phospho Ser641); p-Glycogen synthase 1 (S641); Glycogen synthase 1 (muscle); Glycogen synthase 1; GSY; GYS; GYS1; EC 2.4.1.11; Glycogen synthase1; GYS 1; Starchsynthase muscle; UDP glucose glycogen glucosyltransferase; GYS1_HUMAN; Glycogen [starch] synthase, muscl. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 免疫学 信号转导 转录调节因子 激酶和磷酸酶 合成与降解 糖尿病 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Cat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 85kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human Glycogen synthase 1 around the phosphorylation site of Ser641 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Glycogen Synthase (GS) is a key enzyme in the regulation of glycogen metabolism. GS catalyzes the incorporation of UDP-glucose incorporation into glycogen. The activity of glycogen synthase is regulated by hormonal stimuli (insulin, catecholamines and glucagons) and non-hormonal stimuli (blood glucose level and exercise). Two main isoforms of mammalian GS are designated as muscle (glycogen synthase 1) and liver (glycogen synthase 2). Most tissues express glycogen synthase 1, whereas glycogen synthase 2 appears to be tissue-specific. The two isoforms have 70% identical amino acid sequence. Glycogen synthase can be phosphorylated by multiple kinases including glycogen synthase kinase-3 (GSK-3), mitogen-activated protein kinase-related protein kinase (DYRK), and SAPK2b/p38b which leads to its inactivation. Function: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Subunit: Interacts with GYG1. Post-translational modifications: Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme. DISEASE: Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also known as muscle glycogen synthase deficiency. GSD0b is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work. Similarity: Belongs to the glycosyltransferase 3 family. Database links: Entrez Gene: 2997 Human Entrez Gene: 14936 Mouse Entrez Gene: 690987 Rat Omim: 138570 Human SwissProt: P13807 Human SwissProt: Q8VEB0 Mouse SwissProt: Q9Z1E4 Mouse SwissProt: A2RRU1 Rat Unigene: 386225 Human Unigene: 275654 Mouse Unigene: 95278 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
糖原合成酶（GS）是糖原代谢调控的关键酶。GS催化UDP葡萄糖掺入糖原。糖原合成酶的活性受刺激（胰岛素、儿茶酚胺和胰高血糖素）和非刺激（血糖水平和运动）的调节。哺乳动物GS的两种主要异构体被指定为肌肉（糖原合成酶1）和肝脏（糖原合酶2）。大多数组织表达糖原合成酶1，而糖原合成酶2似乎是组织特异性的。这两种异构体具有70%个相同的氨基酸序列。糖原合成酶可由多种激酶磷酸化，包括糖原合成酶激酶-3（GSK-3）、丝裂原活化蛋白激酶相关蛋白激酶（DYRK）和SAPK2B/P38 B，从而导致其失活。