FITC标记的转化生长因子β活化激酶结合蛋白1抗体
产品名称： FITC标记的转化生长因子β活化激酶结合蛋白1抗体
英文名称： Anti-TAB1/FITC
产品编号： HZ-4135R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TAB1/FITC Conjugated antibody
FITC标记的转化生长因子β活化激酶结合蛋白1抗体
| 英文名称 | Anti-TAB1/FITC |
| 中文名称 | FITC标记的转化生长因子β活化激酶结合蛋白1抗体 |
| 别 名 | MAP3K7IP 1; MAP3K7IP1; Mitogen activated protein kinase kinase kinase 7 interacting protein 1; TAB 1; TAK1 binding protein 1; TGF beta activated kinase 1 binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; Transforming growth factor beta activated kinase binding protein 1; 2310012M03Rik; 3'-Tab1; MGC57664; TAB1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55 kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MAP3K7IP1/TAB1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta and members of the Toll IL 1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N terminus acts as a dominant negative inhibitor of TGF beta, demonstrating how this protein can function as a mediator between TGF beta receptors and TAK1. Function: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Subunit: Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Tissue Specificity: Ubiquitous. Post-translational modifications: Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP. Similarity: Contains 1 PP2C-like domain. Database links: Entrez Gene: 10454 Human Entrez Gene: 66513 Mouse Entrez Gene: 315139 Rat Omim: 602615 Human SwissProt: Q15750 Human SwissProt: Q8CF89 Mouse Unigene: 507681 Human Unigene: 288245 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
TAB1被鉴定为MAPK激酶激酶TAK1/MAP3K7的调节因子，其介导多种细胞内信号传导通路，如TGF-β诱导的和Toll IL 1R（TIR）超家族成员所诱导的，从而作为增殖和先天的中间产物。适应性免疫应答该蛋白与TAB2或TAB3一起，响应上游信号激活TAK1激酶。已经证明，TAB1的C末端部分足以结合和激活TAK1，而N末端的一部分充当TGF-β的显性负性抑制剂，这表明该蛋白可以作为TGF-β受体和TAK1之间的介体。