FITC标记的黑皮质素-1受体抗体
产品名称： FITC标记的黑皮质素-1受体抗体
英文名称： Anti-MC1 Receptor/FITC
产品编号： HZ-1419R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-MC1 Receptor/FITC Conjugated antibody
FITC标记的黑皮质素-1受体抗体
| 英文名称 | Anti-MC1 Receptor/FITC |
| 中文名称 | FITC标记的黑皮质素-1受体抗体 |
| 别 名 | MC1 Receptor; CMM5; MC1-R; MC-1R; MC1R; Melanocortin 1 receptor; Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Melanocortin receptor 1; Melanocyte-stimulating hormone receptor; Melanotropin receptor; MSH-R; MSHR; MSHR_HUMAN; SHEP2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse MC-1R |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This intronless gene encodes the receptor protein for melanocyte -stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. Function: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Subcellular Location: Cell membrane. Tissue Specificity: Melanocytes and corticoadrenal tissue. DISEASE: Genetic variations in MC1R are a cause of susceptibility to cutaneous malignant melanoma type 5 (CMM5) [MIM:613099]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 4157 Human Omim: 155555 Human SwissProt: Q01726 Human Unigene: 513829 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 类固醇受体（Steroid Receptors） |
此无基因编码黑色素细胞刺激（MSH）的受体蛋白。编码的蛋白质，一个七遍跨膜G蛋白偶联受体，控制黑素生成。黑色素存在两种类型：红色黑色素和黑色黑色素。导致功能丧失的基因突变与增加嗜黑素的产生有关，后者导致皮肤和头发颜色变浅。木犀草素具有光保护作用，但嗜黑素可能通过在紫外线照射时产生自由基而导致紫外线诱导的皮肤损伤。MSH与其受体的结合激活了受体并刺激了Euelelin的合成。该受体是日光敏感性的主要决定因素，是黑色素瘤和非黑色素瘤皮肤癌的遗传危险因素。已经鉴定出30多个与皮肤和头发颜色相关的变异等位基因，提供证据表明该基因是确定正常人色素变异的重要组成部分。